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doi: 10.1104/pp.105.066803 46 MahmoodQ.AhmadR.KwakS.RashidA.AnjumN

1 Introduction Sepsis-associated encephalopathy (SAE) represents a severe complication of sepsis, defined by diffuse brain dysfunction without direct central nervous system (CNS) infection ( Oxidative stress is central to SAE pathogenesis, driven by an imbalance between excessive reactive oxygen species (ROS) production and impaired antioxidant defense systems ( The antioxidant defense system, especially GSH metabolism, is linked to neurodegenerative diseases ( Proteomics and metabolomics enable systematic profiling of protein expression and metabolic signatures

Whole grain comprising the bran and germ fractions possess outstanding nutritional and bioactive properties, conferring relevant health-promoting benefits to its consumers and is relevant in weight control (Calinoiu & Vodnar 2018)