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Despite various interactions between ER stress and NF-B, whether and to what extent these mediator molecules play a role in AS remains unanswered

nitric oxide and peroxynitrite are included in RNS

10.3390/ijms22168406 107 LeeY

The administration of a single oral dose of 1,3-dinitrobenzene caused central nervous system toxicity (ataxia) in GF rats but not in conventional rats, whereas repeated oral dosing with 1,3-dinitrobenzene was required to cause ataxia in conventional rats