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Elevated metabolic danger signals, free fatty acids (FFAs), and the bacterial danger signal, LPS, activate the NF-B and MAPK pro-inflammatory pathways, which are regulators of systemic inflammation in obesity, by binding to TLRs (149), resulting in the transcription of pro-inflammatory cytokines, such as TNF-, IL-6, and IL-1, which initiate systemic inflammation (150)

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This signaling is especially important at night, when the body performs much of its healing and repair work

288A (2), 205212

A general structure for plant MT has been proposed for Triticum durum MT type I