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Hansen R, Sb M, Skjelbred CF, Nex BA et al (2005) GPX pro198Leu and OGG1 ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer

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The peptides selected for cancer vaccine development can be classified in two main type: tumor-associated antigens (TAAs) and tumor-specific antigens (TSAs), which are captured, internalized, processed and presented by antigen-presenting cells (APCs) to cell-mediated immunity

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567,568 CD14 + monocytes isolated from the blood of RA patients and individuals at risk have shown higher levels of glycolytic enzymes, including HIF-1, HK2, and PFKFB3, than those from healthy individuals

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This adaptive response may be caused by mutations that deactivate or activate tumor suppressor genes or oncogenes under hypoxic conditions

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