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Description

Clinical or ATPase domain mutations in ABCD4 disrupt the interaction between the vitamin B12-trafficking proteins ABCD4 and LMBD1

NAD + metabolites are excreted through the urine following their conversion to 1-methyl-nicotinamide, and the concept that excess material would be rapidly excreted matches our own data, where NMN treatment drastically increased the production of 1-methyl-nicotinamide (Fig