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True efficacy of these treatments should be validated by largescale nonrandomized twoarm studies between OSpositive and negative groups

To provide further support for this mechanism in patient tumors, we interrogated an integrated dataset (GSE130408) 80 of AR ChIP-seq in patient Pri-PCa and CRPC and observed globally reduced AR enrichment across the BCL-2 genomic region in CRPC compared to Pri-PCa (supplementary Fig

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In addition to glucose metabolism in cancer cells, amino acid metabolism has also become a research hotspot, notably treatments related to the restriction of amino acid metabolism that can selectively target highly proliferative cancer cells (Fig