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NRF2 provides a protective effect in melanocytes in response to both UV irradiation and oxidative stress 30,31 , through transcriptional upregulation of the antioxidant response element (ARE) genes including Superoxide dismutase-1 (SOD-1), Glutathione peroxidase-1 (GP-1), Glutathione reductase-1 (GR-1), Catalase and Heme oxygenase-1 (HO-1) 38,39,40

Computed tomography (CT) revealed multiple masses in the abdomen, liver, and kidneys, with mild sternal and splenic hilar lymphadenopathy

Renal clearance is a secondary route of elimination

Second, this redox imbalance activates stress-sensitive signaling cascades (e.g

Peak plasma concentrations after IM injection are achieved within an hour