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Nat Med 19:202208 Spicer J, Marabelle A, Baurain JF, Jebsen NL, Jossang DE, Awada A, Kristeleit R, Loirat D, Lazaridis G et al (2021) Safety, antitumor activity, and T-cell responses in a dose-ranging phase I trial of the oncolytic peptide LTX-315 in patients with solid tumors

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While synergism and additivity allow for achieving better effects with lower drug concentrations, clinical data suggest that independent drug action can also significantly improve patient outcomes (69)