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The metabolic syndrome is associated with advanced vascular damage in patients with coronary heart disease, stroke, peripheral arterial disease or abdominal aortic aneurysm

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Established benefits of B12 therapy: Treatment of documented deficiency: Intramuscular hydroxocobalamin is the standard NHS treatment for pernicious anaemia and other causes of B12 deficiency, effectively reversing haematological and neurological complications

According to the Global Initiative for Asthma (GINA) 7 , the intent of management is to reduce the burden to the patient and to reduce their risk of asthma-related death, exacerbations, airway damage, and medication side-effects