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Zhang J, Li J, Liu Y, Liang R, Mao Y, Yang X, Zhang Y, Zhu L

Genetic ablation of the A2B receptor in mice systemically exposed to bleomycin (chronic treatment) reduced lung fibrosis exerting modest effects on lung injury, while A2B receptor ablation in mice intra-tracheally treated with bleomycin (acute treatment) increased pulmonary inflammation with little effect on pulmonary fibrosis [136]

Phase II Detoxification: Methylation, Glucuronidation, Sulfation Catechol estrogen metabolites (2-OH and 4-OH) are further neutralized via COMT (catechol-O-methyltransferase) to 2-methoxy- and 4-methoxy-estrogens, reducing their reactivity

The heart, in particular, is highly vulnerable to ROS-mediated damage during hepatic I/R

This examination revealed that MFG treatment significantly prevented DOX-induced LPs and cell death (Figure 7, GI), indicating that DOX-Fe 2+ produced LPs in mitochondria and induced mitochondria-dependent ferroptosis