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Histological analysis on day 7 revealed a significant decrease in the expression of proinflammatory cytokines in the wound, including TNF- and IL-6 in the D-CuP groups, accompanied by an increase in IL-10 expression (Fig

Following damage, the healthy epithelium is restored via a series of signalling pathways that result in remodelling of the scaffolding tissue through finely-regulated proteolysis of the ECM by proteases such as matrix metalloproteinases (MMPs)

Acknowledgements This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No

Document any changes in skin texture, firmness, or healing