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[DOI] [PMC free article] [PubMed] [Google Scholar] 162.Wollenberg A, Blauvelt A, Guttman-Yassky E, Worm M, Lynde C, Lacour JP, et al

131 Intriguingly, pathways through the junctional complex or across the cells actively that participate in transport of ions, nutrients and other molecules could also be potential routes for drug delivery, which is discussed in detail in Section 3.1

The reasons for the differences in effectiveness in different cancer cell lines remain unexplained as neither the cellular accumulation of the prodrug nor the expression of the Tb HGPRT gene can justify the differences in cytotoxicity observed among the tested cell lines [158]

Expected timeline to market If the TRIUMPH trials produce results consistent with Phase 2, regulatory submission could occur as early as late next year, with approval and market availability following twelve to eighteen months later

Access this article Similar content being viewed by others References Abdullateef B, Kolo BG, Waziri I, Idris MA (2014) Levels of heavy metals in soil as indicator of environmental pollution in Maiduguri, Borno State, Nigeria