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Second line treatment was given to 6 patients, including FOLFOX (n=3) and ivosidenib (n=3)

Indeed, expression of key SREBP2 downstream genes (e.g., LDLR, HMGCR) is lower while expression of SREBP2 inhibitory genes (e.g., INSIG1, AMFR) is higher in rSCC-61 compared to SCC-61 cells ( Figure S6B ) bringing support to regulation at the level of gene expression

In a PTSD mouse model, microglia proliferate and adopt an activated morphology characterized by enlarged cell bodies, simplified branching, and dendritic spine loss in the hippocampal CA1 region changes that likely underlie memory deficits and emotional dysregulation (165, 166)

Lourenco, S., Oliveira, A

Mustian, K