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Yet as our understanding of cellular signaling and regulatory pathways has developed, so has our insight into the involvement of GSH homeostasis in many other key processes, including the regulation of cellular proliferation and apoptosis and the post-transcriptional modification of proteins through S-glutathionylation, as well as the importance of GSH in the detoxification of hydroperoxides and diverse xenobiotic compounds

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Under hypoxic microenvironment, HIF-1 regulates the migration and invasion of RA FLS and angiogenesis through the Notch-1 pathway (134)