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Previous studies have shown a high degree of overlap between ferroptosis and PD pathophysiological features, such as iron overload, increased lipid peroxidation, reduced glutathione levels, downregulation of the cystine-glutamate antiporter system (System xc-), and decreases in DJ-1 and coenzyme Q10 (CoQ10) 7

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In the following narrative, we summarize the compounds that have become more popular in HCC therapy in the last few years, which are able to inhibit HCC cells in different pathways from ferroptosis, and may play a great role in the future of hepatocellular carcinoma therapy ( Table 1 )

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