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Lower 5-HT4 receptors and greater occupancy by escitalopram was correlated with poorer verbal affective memory, but not depressive symptoms, suggesting that 5-HT4A receptors could represent a promising therapeutic target for cognitive deficits [117]

Examples of such medications include (Antonelli 2015

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doi: 10.1016/s0076-6879(99)03014-1

FIGURE 3 The Fh8-HIC methodology presented also the advantage of being compatible with the IMAC technique, thus, allowing a dual protein purification strategy that can be used sequentially, complementing each other, to obtain an active and more purified protein when desired