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Compounds mentioned above are nonspecific NADPH oxidase inhibitors and are not able to discriminate between different isoforms of NOX (with the exception of ebselen, which was later shown to hinder the activity of NOX-1, NOX-2, and NOX-5 at lower concentrations than its glutathione peroxidase mimetic activity

doi: 10.1016/j.tibtech.2004.03.007 32 Schrimpe-RutledgeACCodreanuSGSherrodSDMcLeanJA

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