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Combination approaches simultaneously address multiple bottlenecks, enabling faster overall progress through the repair cascade

They revealed that BHD diminishes lactylation modifications, including Pan-Kla and H3K18la, by restricting lactate synthesis, which leads to the normalization of apoptotic protease activating factor-1 (Apaf-1) transcription levels and ultimately promotes cellular survival [126]

Previously, we found that rotenone could negatively regulate mTOR-mediated p70S6K and 4E-BP1/Eif4E pathways, that leads to caspase-3 dependent neuronal apoptosis in vitro 15