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63 Furthermore, BCAT 1 is selectively upregulated in isocitrate dehydrogenase (IDH) wild-type (WT) GBM, and -ketoglutarate (-KG) mediates cell death in BCAT 1-deficient IDH WT GBM

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Subsequent cellular invasion (internalization) of the pathogen takes place as the viral S-protein/host receptor complex is primed by furin cleavage at two sites: S1/S2 and S2