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10.1016/j.jep.2008.07.041 [DOI] [PubMed] [Google Scholar] Lee J., Roh T., Rho M., Kim Y., Lee H

Bone, lung, liver, and brain are the most frequent metastatic sites, and each sites possess different microenvironments to favor survival of metastasizing cancer cells [ Figure 3I ] (186, 187)

313 The optimized successor of GKT137831, Setanaxib, overcomes PD-1/PD-L1 resistance by targeting NOX4 in cancer-associated fibroblasts, reversing their immunosuppressive phenotype, and enhancing CD8 + T-cell infiltration