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Autoimmune responses can be divided into two categories: adaptive and innate (Das et al., 2019)

Multiple clinical studies have shown that individuals with the MetALD phenotypedefined by the coexistence of metabolic dysfunction and alcohol consumptionexhibit significantly higher levels of transaminases, fibrotic markers (e.g., PIIINP, TIMP-1), and oxidative stress biomarkers than those with MASLD alone, suggesting a synergistic effect of alcohol on fibrotic progression [38,51]

The excess of BCPB was studied in the molar range from 1 to 150 and the time of derivatization was controlled in the range from 1 to 30 min (Fig

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