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99 Wu et al

Another case study reported that high-dose oral thiamine supplementation (750 mg/day) improved the symptoms of chronic cluster headache, and confirmed its role in pain modulation (21)

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10.1586/14737140.2015.992418 125 KedirW

Oxidative stress caused by inflammation can activate microglia, astrocytes, and oligodendrocytes, resulting in their release of inflammatory mediators and oxygen-free radicals, which in turn damage nerve cells and nerve fibers