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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)

Injection Technique General subcutaneous guidance from clinical best-practice resources [7] [8]

Appetite Modulation: Studied for Cagrilintides unique ability to activate neurons in the area postrema, distinct from GLP-1 pathways

Each is the latest step in a distinct multi-decade research lineage, and understanding those lineages explains why the two look so different despite chasing the same endpoint

In some circumstances, dyskinesia can also affect speech as well as respiratory and eye muscles