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Choo BKM, Kundap UP, Kumari Y, Hue S-M, Othman I, Shaikh MF

Combination therapy leads to supraphysiologic levels of T3, which may lead to symptoms of thyrotoxicosis T3 has a shorter half-life than T4, which can lead to fluctuations in T3 levels, with a peak occurring shortly after dosing There is substantially more data from trials on the use of levothyroxine compared to combination therapy In my experience, patients who are on animal-derived combination products have already tried synthetic levothyroxine and feel that the combination products control their symptoms better

14,249,250 Based on this characteristic, CRM hydroxycitrate has been shown to increase sensitivity to chemotherapy by eliciting an adaptive cellular immune response, resulting in a decrease in the number of tumor-infiltrating Tregs into the tumor niche in various tumor models

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The important interplay between exogenous and endogenous antioxidants will be discussed in the next section