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On the other hand, the lack of a significant anxiolytic effect with GABA treatment raises questions about its bioavailability or receptor interactions in the specific context of the EPM test, possibly due to differences in the route of administration, dosage, or the animal models specific pathology

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Furthermore, the DML c is situated within regulatory regions that contain binding sites for EZH2, CTCF, GPS2, and TCF21 across various cell types 63

Gurvich, V.B

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