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Such a superior affinity, in consequence, suggests a prolonged half-life in vivo

Krauth-Siegel et al., studied the Y197S variant of GR and concluded the diminished accumulation of FAD-NADPH charge transfer and the overall decrease in the rate constants observed for reduction were evidence of Y197 directly participating in the flavin reduction event ( To determine the functionality of the Y296 residue in SmTGR, a study of the reductive half-reaction of the Y296A variant was performed

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