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Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning

This might meet the possibility for shielding ability of MT binding on the membrane and thereby reduced the sensitivity of ROS to root tips

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The effectiveness of romiplostim for this use was only studied in animals because it could not be studied in people