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The interaction of m11 with CD44 impairs the trafficking of dendritic cells within the spleen, thereby impeding efficient priming of naive T cells and the initiation of antiviral CD8 T cell responses

(10 pts) Oxidant Reductant RE(V) Succinate -CO a-ketoglutarate 2 -0.67 Acetate Acetaldehyde 2 0.60 Ferredokan (oxidized) Ferredoxin (reduced) 1 -043 2 H HE 2 042 NAD: NADH-H 2 -0.32 NADP NADPH-H 2 -0.32 Lipoate oxidured) Lipoate reduced 2 -0.29 Glutathione (oxidized) Glutathione (reduced) 2 03 EAD EADH 2022 Acetaldehyde Ethanol 2030 Pyruvate Lactate 2 019 Fumarate Succinate 003 Cytochrome (+3) Cytochrome (+2) 0.07 Dehydroascorbate Ascorbate 2 0.08 Ubiquinone (oxidured) Ubiquinone (reduced) 2 010 Cytochronne(+3) Cytochrome (2) 0.22 Fe(+3) Fe (-2) 0.77 02-27 HO 2 2 1

DFO, an FDA-approved iron chelator, effectively reduces hydroxyl radical generation and attenuates brain injury in experimental stroke models (150, 151)

Phagocytic leukocytes also produce and release cytokines, including interferons, which have antiviral activity (87)

Endocrinol Metab (Seoul)