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IRE1 activates JNK through TNF receptor-associated factor (TRAF2) binding, triggering inflammatory signaling cascades

Further investigations should aim to clarify how Nrf2 influences ferroptosis across different tumor contexts, and how its modulation interacts with oncogenic signaling, iron metabolism, and immune regulation

Adylova A, Kapanova G, Datkhayeva Z

Therefore, a deeper understanding of the regulatory and signaling mechanisms of NAC on macrophages and other innate immune cells involved in bone metabolism will further inform its application in bone tissue engineering

Polyphenols from pinecones of Pinus koraiensis induce apoptosis in colon cancer cells through the activation of caspase in vitro