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Alternatively, different cells (LSCs and HT1080 cells in this case) may have distinct responses to the same stimulation, as has been shown by others 41

Transmission electron microscopy revealed mitochondrial membrane rupture, fragmentation, and mitochondrial cristae fragmentation and disappearance

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Neutralizing antibody against PAI-1 attenuated p65 activation in IL-1 treated hepatocytes and blocked PAI-1 induction completely, suggesting the freely released PAI-1 is required to fully activate p65 and induce PAI-1