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10.1038/nm1267 137

However, with the rise of vitamin supplementation, questions arise about the safety and potential for overdose on vitamin B12

& Leclerc, P

Another study investigating metabolomic profiles in murine macrophages treated with iron show increased levels of NADPH and 6-phosphogluconic acid, indicating the potential involvement of other factors, in addition to HIF1, in the iron-mediated regulation of the PPP (195)