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The biological relevance of this phenomenon is essential since several opsonizing proteins (such as complement factors, coagulation factors, and immunoglobulins) rely on conformational changes in order to activate their respective signaling cascades, and otherwise, some di per se non-immunogenic proteins may expose new epitopes that can trigger subsequent opsonization

Rheumatology 54 (2), 363368

HodgsonE.2004A textbook of modern toxicology, John Wiley & Sons, Inc., Retrieved from 52

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