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Valproate has varying effects depending on the stage of brain development, as it can be toxic in embryogenesis (Laegreid et al., 1993) and prenatal valproate in rodents has been used to model autism in rats (Ingram et al., 2000), mice (Yochum et al., 2008) and zebrafish (Li et al., 2024)

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This process is distinct from the ketosis that occurs during fasting or calorie-restricted diets [22]

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Materials and methods: A total of 929,982 subjects with ( n = 154,997) or without ( n = 774,985) RA from the National Health Insurance Service (NHIS) database in Koreas (corresponding to the period between 2009 and 2017) were retrospectively analyzed