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Mitochondrial diseases in humans can arise from a myriad of mutations in mitochondrial and nuclear (cellular) DNA [4]

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Patients should be encouraged to consume B12-rich foods, including: Meat, particularly liver and kidney Fish and shellfish Dairy products (milk, cheese, yoghurt) Eggs Fortified breakfast cereals and plant-based milk alternatives For patients following plant-based diets, fortified foods and supplementation become essential, as vitamin B12 is naturally found almost exclusively in animal products

LaiYWangJYueNZhangQWuJQiWet alGlutathione peroxidase-like nanozymes: Mechanism, classification, and bioapplication

Bioavailability is paramountthe supplement must be absorbed and reach the liver in sufficient quantities to exert potential benefits