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Early small trials suggested that TUDCA might slow functional decline in ALS patients, leading to larger studies.38 TUDCA was later tested in combination with sodium phenylbutyrate (marketed as Relyvrio/AMX0035)

Infections causing hearing loss tend to occur more often in children and young adults

Besides, prolonged elevation of ROS levels causes increased consumption of IgM antibodies and suppresses antibody production by downregulating CD19 expression [151, 152]