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Niacin is the most effective HDL-Craising therapeutic agent available and can increase plasma HDL-C by up to ~30%, although some patients fail to achieve clinically important increases in HDL-C levels from niacin therapy

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The asymptomatic mothers in Families 1, 4, and 5 along with those previously reported in the literature 14,18,19 indicate that individuals with CDSP can be asymptomatic

Future studies therefore should envisage to identify HCV-HIV coinfected individuals in clinical cohorts allowing an in-depth characterization of immune status and the presence of HCV high replicator variants