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In this work, we found that SP and SP@M could down-regulate the expression level of KEAP1 in vitro (Fig

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The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells

83,84,85 Mechanistically, autophagy stabilizes PPAR2, a master transcriptional regulator of adipogenesis

Though several investigations have shown that EGCG and other catechins in green tea augment the activity of antioxidant enzymes and reduce oxidative stress markers and inflammatory markers (Reference Ye, Ye and Xu19Reference Bogdanski, Suliburska and Szulinska22) , there are equivocal effects on markers of oxidative stress, and inflammation in diabetes, metabolic syndrome, -thalassemia major, and obesity (Reference Lasaite, Spadiene and Savickiene15,Reference Azizbeigi, Stannard and Atashak23Reference Basu, Du and Sanchez28)