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Biochim Biophys Acta Proteins Proteom 1867(10):890908

[DOI] [PMC free article] [PubMed] [Google Scholar] Seidl R, Cairns N, Singewald N, Kaehler ST, Lubec G

Over time, poorly controlled blood sugar increases the risk of cardiovascular disease, nephropathy, retinopathy, and neuropathy

Although non-redox metals do not directly participate in redox reactions, Pb 2+ can disturb mitochondrial redox homeostasis by suppressing the antioxidant activity of reduced glutathione (GSH) or antioxidant enzymes (mtSOD (SOD2), catalase, glutathione peroxidase) as a result of the interaction of Pb 2+ with protein -SH groups

Another critical challenge is the lack of well-defined immunological correlates or biomarkers of protection