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For example, compounds of formula (VI) wherein X is chloro may be prepared treating the corresponding carboxylic acid with thionyl chloride in a suitable solvent or mixture of solvents

Here, several mediators can regulate apoptosis of HCs, including c-Jun N-terminal kinase (JNK), which activates apoptosis by upregulating the transcription of the pro-apoptotic gene such as TNF-, Fas-L, and Bak [143]