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Daily administration of two or more synaptogenic compounds simultaneously might overwhelm cellular synthetic capacity or trigger compensatory downregulation faster than either compound would alone, potentially favoring alternating administration schedules where different compounds are used on different days

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When labelled with 123Iodine it can be visualised using cardiac scintigraphy, and quantified by comparing uptake in a region of interest over the heart with a control region over the mediastinum, providing the heart-mediastinum ratio (Fig