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Berberine may modestly reduce total cholesterol, LDL cholesterol, and triglycerides in some studies, whilst L-carnitine has been examined in the context of cardiovascular health

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GSH is a crucial antioxidant for maintaining redox balance, and glutathione peroxidase 4 (GPX4)the principal enzyme responsible for scavenging LPO via GSHis impaired when GSH levels drop, eventually leading to excessive accumulation of LPO and, ultimately, ferroptosis

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[44] In the cytosol [edit] Methylcobalamin and 5-methyltetrahydrofolate are needed by methionine synthase in the methionine cycle to transfer a methyl group from 5-methyltetrahydrofolate to homocysteine, thereby generating tetrahydrofolate (THF) and methionine, which is used to make SAMe

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