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Classical homocystinuria has been recognised as a protein misfolding disorder as many of the known pathogenic mutations result in aggregation and degradation of the CBS enzyme 9,10

Recent findings indicate that BCP alleviates oxidative stress, inflammation, and apoptosis, demonstrating a protective effect against doxorubicin-induced cardiotoxicity (Meeran et al., 2019)

doi: 10.1186/s13073-016-0299-7

The rest of the binding sites non-specifically interacted with other slightly charged proteins, such as histidine-rich protein, leading to impurities later on

However, it is essential to note that GSH levels in both dose groups generally returned to baseline levels after a one-month washout period, suggesting that continuous supplementation is necessary to maintain elevated GSH levels