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Exposure of proteins to HOCl results in a broad range of modifications that have been very recently summarized in an excellent review by Hawkins [225] and only a short overview, based mostly on experimental data from the Davies and Hawkins groups, will be given here and in Fig

More recently, a study conducted in human colon carcinoma HCT116 cells showed that lithocholic acid (LCA), a secondary bile acid, stimulates IL-8 expression and induces endothelial cell proliferation and tube like formation in the tumour microenvironment, providing the strong evidence for LCA as a tumour promoter in CRC (126)