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NADH autofluorescence-A marker on its way to boost bioenergetic research

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doi: 10.3390/antiox9050405 32 Mohd MutalipSSAb-RahimSRajikinMH

CVD is a complex disease that involves multiple environmental and genetic factors, particularly atherosclerosis (AS), which mainly affects the large and middle arteries (3)

In this process, the molecules NADH and FADH 2 - derived from the TCA cycle or from the OXPHOS cycle of fatty acid metabolism - are oxidized and thereby function as electron donors in a series of redox reactions (also referred to as the electron transport chain) with oxygen as ultimate electron acceptor (Mehta et al., 2017