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Clemastine was shown to promote remyelination in an LPC-induced mouse model of spinal cord demyelination (Mei et al., 2014

Historically our shorthand for the rise and fall of national drug crises distilled down to dangerously simple explanations, see the "crack babies" fiasco

Figure 3B shows knockdown of the target protein (if it is expressed on the surface) in the same M2 macrophage as measured by flow cytometry analysis

Compounds were dissolved as 1.5 mM DMSO stocks

The medication is initiated at a lower dose and gradually titrated upward to minimize gastrointestinal side effects and optimize therapeutic response