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Hepatic lipid metabolism is primarily governed by the activation of the sterol regulatory element-binding protein 1c (SREBP1c) pathway, also known as the I-Rec pathway

In contrast, expression of the K63 ubiquitin mutant (HA-Ubi-K63) further increased the phosphorylation of endogenous GSK3 at Ser9 and its mitochondrial translocation by APAP treatment compared with the results obtained with HA-Ubi-WT and HA-Ubi-K48 (Fig