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However, it is possible that the combined effect of ALDH1A1 and ALDH2 polymorphisms may lead to considerable variability in alcohol metabolism, affecting tolerance, dependence, and alcohol-related diseases across individuals and populations

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IGF-1 availability is tightly regulated by the so-called insulin-like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF-1R) [9395]

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[DOI] [PubMed] [Google Scholar] 2.Rogers LM, Boy E, Miller JW, Green R, Sabel JC, Allen LH