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TRANSCRIPTOMIC DIFFERENCES BETWEEN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS, WITH AND WITHOUT ULCERATIVE COLITIS Kiandokht Bashiri 1 Camille Boustani 2 Spyridon Peppas 3 Alireza Meighani 3 Won Kyoo Cho 4 , 1 Georgetown University/ MedStar Washington Hospital Center, 2 MedStar Georgetown University Hospital, 3 MedStar Washington Hospital Center, 4 Georgetown University School of Medicine Background: The majority of patients with Primary sclerosing cholangitis (PSC) develop ulcerative colitis (UC)

Para O, Crispino P, Barone N et al (2018) Sex differences in adverse drug reaction and liver disease

When administering subcutaneous injections, the abdomen and upper thigh are the most preferred sites, but other areas such as the upper arm and buttocks may also be used

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recombinant antibody refers to antibodies that are prepared, expressed, created or isolated by recombinant means, such as (a) antibodies isolated from an animal e.g., a mouse) that is transgenic or transchromosomal for immunoglobulin genes (e-g, human immunoglobulin genes) or a hybridoma prepared therefrom, (b) antibodies isolated from a host cell transformed to express the antibody, e.g., from a transfectoma, (c) antibodies isolated from a recombinant, combinatorial antibody library (e.g., containing human antibody sequences) using phage display, and (d) antibodies prepared, expressed, created or isolated by any other means that involve splicing of immunoglobulin gene sequences (e.g., human immunoglobulin genes) to other DNA sequences