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Introduction Acquired pure red cell aplasia (aPRCA) is a very rare anemia due do the failure of erythropoiesis, causing profound reticulocytopenia, with an estimated annual incidence of 1.06 per million

However, in line with the specificity of CPA, the C-terminal residues of the L585I, L585M, and L585V variants were cleaved in vitro upon exposure to the enzyme for 5 hours at 37 C, as confirmed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis of the C-terminal peptides (Supplementary Table 1)

We're standing at the threshold of a new era in musculoskeletal medicine, one that is shifting away from mechanical fixes and toward biological enhancement

Exome sequencing and mitochondrial genome testing showed no variants consistent with genetic disorders of cobalamin metabolism or hereditary neuropathies