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AAs potently activate mTORC1 via AA-sensing GTPase activity towards Rags (GATOR) [33]

J Clin Invest 2008

Moreover, it emphasizes the central role of mitochondrial dysfunction and oxidative stress in multiple organ failure

The ABCB1 gene encodes P-glycoprotein (P-gp), an ATP-dependent efflux pump highly expressed in brain capillary endothelial cells, which actively transports a wide range of xenobiotics from the brain interstitial space back into the systemic circulation (Skinner et al., 2023)

Treatment modalities involving the administration of ferroptosis inhibitors, GPX4 activators, and classical and modern interventions, such as Jianwei Shoutai Pill and ferrostatin-1, now offer new avenues to modulate